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Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health (RW-2018)

Jan 22 | 8:00AM - 4:00PM

Pre-Conference Course

Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health (RW-2018)

The goal of the Research Workshop, The Effect of Nutrition on Epigenetic Status, Growth, and Health, is to focus on influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence disease incidence and severity over multiple generations.

A growing compendium of research indicates that the incidence and severity of common and costly human diseases are influenced by dietary exposures and deficiencies that modify the epigenome. The greatest periods of vulnerability to these exposures are the periconceptual period and early childhood. Xenobiotics delivered through the food chain, protein malnutrition, methyl donor deficiencies, and excesses have a profound bearing
on the risk of developing heart disease, diabetes, obesity, hypertension, and mental illness over several generations. The financial impact and the life burden of these diseases are enormous. Knowledge of the influences of nutrition on the epigenome is well understood in the scientific community, but is poorly disseminated among healthcare providers who make critical clinical decisions for patients and also influence nutrition policy. 

The workshop  is leveraged to address the existing gap  between the bench and the bedside.  The workshop will provide a venue  for inter-disciplinary collaboration  among early career and established  researchers from basic, applied, and  clinical outcomes science who are  seeking opportunities to improve health  and reduce disease burden through  scientifically valid nutritional strategies.  This workshop brings together nutrition  researchers from ASPEN with experts  from the fields of developmental biology, epigenetics, population biology, and pediatric nutrition support. This milieu will facilitate research collaborations where they might not otherwise occur. This topic is of key relevance to ASPEN researchers, and indeed for health care delivery policy. 

  1. Summarize clinically relevant and cutting-edge research on the mechanisms by which nutrition modulates the epigenetic risk for disease in adulthood, thus bridging basic research and clinical care
  2. Translate science by fostering communication and collaboration among interdisciplinary researchers and clinicians thus bringing research from bench to bed-side

The Ukraine Holomodor, Dutch Hunger Winter and China’s Great Leap Forward: What Famines Can Teach Us About Disease Acquired During Gestation
L.H. Lumey, MD, PhD

Epigenetic Transgenerational Inheritance for Disease and Lifestyle Choices
Michael Skinner, PhD

Environment Around Conception and its Legacy for Lifetime Disease Risk Through Epigenetic and Physiological Mechanisms
Tom Fleming, BSc, PhD

Periconceptual and Pre-natal Exposures of the Epigenome: the Molecular Fossil Record
Carmen Sapienza, PhD

Epigenetics: How Genes and Environment Interact 
Randy Jirtle, PhD

Cadmium and Lead Exposure, Epigenetics and Cardiometabolic Dysfunction Indicators
Cathrine Hoyo, PhD

Epigenetics and Personalized Medicine
Lucia Aronica, PhD

Operationalizing Epigenetics within Healthcare–A 30,000 Feet View
Jeff Thompson, MD

Peter Nichol, MD, PhD

UAN: J0002345-0000-18-003-L04-P
CE CREDIT: 6.5 hours

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD094514. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.