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Research Workshop: The Relationship Between the Intestinal Barrier and Chronic Disease (RW-2019)

Mar 23 | 7:30AM - 4:00PM

Pre-Conference Course

Research Workshop: The Relationship Between the Intestinal Barrier and Chronic Disease (RW-2019)

In the U.S., 86% of the nation’s $2.7 trillion annual health care expenditures are for individuals with chronic and mental health conditions. A growing body of evidence indicates that a compromised intestinal epithelial barrier influences the incidence and severity of these chronic diseases, such as type 1 and 2 diabetes and obesity, primary intestinal disorders such as celiac disease and inflammatory bowel disease, and neurologic disorders such as autism and Parkinson’s disease. A healthy intestinal epithelium forms a barrier between the host and environment, and the intestinal microbiota educates and maintains the host intestinal health and immune system. An altered intestinal epithelial barrier allows translocation of antigens and pathogens from the intestinal lumen into the host. The translocation of antigens and pathogens promotes further intestinal epithelial barrier disruption leading to a systemic chronic inflammatory state associated with the development and persistence of disease. Despite growing evidence linking diet, environment, the intestinal epithelium, and inflammatory diseases, there is a gap between the science and healthcare policy and practice. This large gap presents an enormous opportunity to develop scientifically based strategies, healthcare policies and clinical guidelines to prevent and reduce the risk of chronic inflammatory diseases with the aim of developing interventions that promote an intact and healthy intestinal epithelium. To this end, it is crucial that health care providers understand how nutrition, environment, microbiota, and intestinal epithelium interact. This workshop addresses an important and evolving field of research with potential for clinical impact that you will not want to miss.
Welcome and Introductions
Kelly Tappenden, PhD, RD
Yimin Chen, PhD, RD, CNSC 
Enid E. Martinez, MD
Overview of the Intestinal Epithelial Barrier
Jerrold Turner, MD, PhD
Intestinal Epithelial Barrier and the Human Microbiome
Gary D. Wu, MD
Role of Nutrition as a Modulator of Intestinal of Intestinal Barrier Health and Disease
Kelly Tappenden, PhD, RD
Intestinal Epithelial Barrier and Obesity/Metabolic Syndrome
Daniel Winer, MD
Intestinal Epithelial Barrier and Autoimmune Diseases
Alessio Fasano, MD
Intestinal Epithelial Barrier and the Neurologic System – Gut-Brain Axis
Brittany Needham, PhD
Circadian Rhythms and the Intestinal Barrier
Amir Zarrinpar, MD, PhD
Synthesis of Presentations/Panel Discussion 
All faculty
Yimin Chen, PhD, RD, CNSC 
Enid E. Martinez, MD 

  1. Describe the properties and functions of the intestinal epithelial barrier.
  2. Describe how the microbiota and nutrition modulate the intestinal epithelial barrier.
  3. Summarize how the intestinal epithelial barrier impacts risk for various chronic inflammatory diseases.
  4. Evaluate the current literature on factors that influence intestinal epithelial barrier integrity.
  5. Explore opportunities for translational science from communication and collaboration among interdisciplinary researchers and clinicians that can bring about changes in health care practice and public policy relevant to the management and prevent of inflammatory-based chronic diseases.
UAN: JA0002345-0000-19-006-L04-P
CE CREDIT: 6.5 hours