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What Causes Multiple Organ Failure (MOF) in Critical Illness?

4:00 PM - 6:00 PM


  1. Describe how the response to critical illness and injury leads to dramatic pathophysiologic changes resulting in adverse outcomes and mortality
  2. Identify factors that contribute to MOF in critical illness
  3. Explain how innovative strategies in nutritional therapy can alleviate or reverse factors that cause MOF in critical illness

Ischemia, Hypoxia, and Shock:  The Primary Drivers of Multiple Organ Failure in Critical Illness 

Robert G. Martindale, MD, PhD, Professor of Surgery, Division of Gastrointestinal and General Surgery, Department of Surgery, Oregon Health & Science University School of Medicine; Medical Director, Hospital Nutritional Service, Oregon Health & Science University, Portland, OR

Conversion of a Commensal Microbiome to a Virulent Pathobiome Drives Multiple Organ Failure
Paul E. Wischmeyer, MD, EDIC, Professor of Anesthesiology and Associate Vice Chair for Clinical Research, Department of Anesthesiology; Director, Perioperative Research, Duke Clinical Research Institute (DCRI); Duke University School of Medicine, Durham, NC

Immune Dysregulation and Gut Sepsis Cause Multiple Organ Failure in the ICU 
Craig M. Coopersmith, MD, FACS, FCCM, Professor of Surgery, Vice Chair of Research, Program Director, Surgical Critical Care Fellowship, Department of Surgery, Emory University School of Medicine; Interim Director, Emory Critical Care Center, Emory University; Director, Surgical/Transplant Intensive Care Unit, Emory University Hospital, Atlanta, GA

Mitochondrial Failure:  A Maladaptive Cellular Response that Leads to Multiple Organ Failure in Critical Illness 
Zudin Puthucheary, MBBS, BMedSci, DUHM, PGCME, EDICM, MRCP, FHEA, FFICM, PhD, Clinical Senior Lecturer, William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

Stephen A. McClave, MD, FACN, FASGE, FASPEN, AGAF, Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky     

CE Credit: 2 hours
Level: Advanced
UAN: JA0002345-0000-20-029-L01-P

Presented by the ASPEN Physician Engagement Committee